Kidney transplant from pig to human successful in new test

WHAT YOU NEED TO KNOW:

• US surgeons were able to temporarily attach a pig’s kidney to a human patient and watched it begin to function.
• The procedure is a success in the attempt to one day use animal organs for life-saving transplants.
• In the experiement, scientists used a kidney from a genetically- engineered anima.

Surgeons have successfully transplanted a pig kidney into a human patient without causing immediate rejection by the recipient’s immune system. The experiement can eventually help in the shortage of human organs for transplant.

The procedure done at NYU Langone Health in New York City involved use of a pig whose genes had been altered so that its tissues no longer contained a molecule known to trigger almost immediate rejection.

The recipient was a brain-dead patient with signs of kidney dysfunction whose family consented to the experiment before she was due to be taken off of life support, researchers told Reuters.

For three days, the new kidney was attached to her blood vessels and maintained outside her body, giving researchers access to it.

Test results of the transplanted kidney’s function “looked pretty normal,” said transplant surgeon Dr. Robert Montgomery, who led the study.

The kidney made “the amount of urine that you would expect” from a transplanted human kidney, he said, and there was no evidence of the vigorous, early rejection seen when unmodified pig kidneys are transplanted into non-human primates.

The recipient’s abnormal creatinine level – an indicator of poor kidney function – returned to normal after the transplant, Montgomery said.

In the United States, nearly 107,000 people are presently waiting for organ transplants, including more than 90,000 awaiting a kidney, according to the United Network for Organ Sharing. Wait times for a kidney average three-to-five years.

Researchers have been working for decades on the possibility of using animal organs for transplants, but have been stymied over how to prevent immediate rejection by the human body.

Montgomery’s team theorized that knocking out the pig gene for a carbohydrate that triggers rejection – a sugar molecule, or glycan, called alpha-gal – would prevent the problem.

The genetically altered pig, dubbed GalSafe, was developed by United Therapeutics Corp’s Revivicor unit. It was approved by the U.S. Food and Drug Administration in December 2020, for use as food for people with a meat allergy and as a potential source of human therapeutics.

Medical products developed from the pigs would still require specific FDA approval before being used in humans, the agency said.

Other researchers are considering whether GalSafe pigs can be sources of everything from heart valves to skin grafts for human patients.

The researchers worked with medical ethicists, legal and religious experts to vet the concept before asking a family for temporary access to a brain-dead patient, Montgomery said.

Source: Reuters